Down-regulation LncRNA-SNHG15 contributes to proliferation and invasion of bladder cancer cells

Abstract Objectives The aim of this study was to investigate the effect lncRNA-SNHG15 in bladder carcinoma using cell lines experiments and relationship between clinical characteristics expression analyzed. Methods Bladder cancer tissues near-cancer were collected. real-time PCR (RT-PCR) used detect lines. downregulated by interference (siRNA), as detected RT-PCR, that determine efficiency interference. CCK-8 Transwell assays evaluate on proliferation invasion capability cells. t-test for Statistical analyses, which carried out Graph pad 8.0.1.224 software. Result up regulated 5637, UMUC3 T24 compared with corresponding normal controls ( P < 0.05). Up regulation positively related tumor stage = 0.015). And size 0.0465). down-regulation siRNA significantly inhibited invasion. Conclusion This showed is overexpressed (5637, T24) 0.015), Down-regulation invasion, indicating a potential molecular target future targeted therapy.